Tuesday, June 21, 2011

IB Chemistry, Depressants, Tranquilizers, Neurotransmitters, Serotonin, GABA, Prozac, Medicine Drugs Option D

Depressants, Antidepressant, Tranquilizers
This post is dedicated in memory of MJ death on 25 June 2009. Avoid  these drugs unless needed on doctor's prescription.
IB Keywords
source:http://luckynews.co.tv/


Neurotransmitters affecting Depression/Anxiety


http://www.healmindbody.com/Services/Body-And-Mind/Neurotransmitter-Restoration.aspx
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Different Antidepressants - SSRI, SNRI, NRI, TCA, TeCA, MAOI . Click HERE for list
Different Tranquilizers - Benzodiazepines (BZD), Barbiturates. Click HERE for list

Antidepressant for IB - SSRI
Selective Serotonin Reuptake Inhibitors (SSRI)
Information on SSRI
  • (SSRI) or selective serotonin reuptake inhibitor 
  • Fluoxetine (Prozac)/newer drug
  • Most popular/less side effect compared to others
  • SSRI among Top 12 best selling antidepressant drugs. Click HERE to view
  • Many side effect, including low sex drive
Fluoxetine (Prozac) an antidepressant of the SSRI -  increase the neurotransmitter serotonin by inhibiting its reuptake into presynaptic cell, increasing serotonin level in synaptic cleft 


Serotonin Structure
  • Serotonin - Neurotransmitter
  • Feel good hormone, control mood /well being 
  • Made from amino acid  tryptophan
  • High level need to avoid depression
  • Serotonin broken down/ reuptake by transporter
  • Turkey source of tryptophan, which explain why people often feel relaxed and sleepy after Thankgiving!
How Prozac (SSRI) or (SNRI) works

  • SSRI inhibitor /block the reuptake of Serotonin
  • Serotonin level in brain synapse up
  • SSRI for Serotonin, increase Serotonin level
  • SNRI for Norepinephrine, increase Norepinephrine level
  • (Cymbalta) duloxetine , example of SNRI


Prozac Structure
  • Amine gp, basic (lone pair)
  • Amine reacts with HCI forming hydrochloride salt, 
  • Fluoxetine(Prozac) salt, protonated /polar and water soluble




Video Animation, How SSRI (Prozac works)

Click HERE for detail video on How Prozac works.
Keywords from video
  • SSRI inhibit Serotonin reuptake transporters
  • Serotonin stays in synapse, higher Serotonin level
Latest SSRI antidepressant drug this year (2011)
Click HERE to view and HERE for drug info


Video on Latest antidepressant drug

Keynotes from video
  • Latest FDA approved Lilazodone (Viibryd), SSRI antidepressant
  • Increases Serotonin level
  • Less side effect compared to others, does not reduce sex drive (sex friendly)
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Tranquilizers for IB - Benzodiazepines (BZD)
Benzodiazepines (BZD) acts as tranquilizers, enhances the effect of the neurotransmitter GABA, leads to hypnotic, sedation, drowsiness, treating insomia.


Diazepine Structure
  • Benzene ring
  • diazepine (7-member heterocyclic ring)
  • Amine gps
  • Valium, Librium and Nitrazepam have diff side gps
  • Valium, popular in 1970, used by MJ
How BZD works affecting Neurotransmitter (GABA)
  • BZD binds to receptor, enhances the GABA binding 
  • GABA binding lead to diffusion of CI ion
  • CI ions causes hyperpolarisation (nerve cell resistant to excitation) 
  • Results in sedation, hypnotic, treat insomia, stress, anxiety
  • Side effect - Tolerance, Dependence and Withdrawal 
  • BZD (Valium and Xanax) most popular 
  • Lots of side effect!!!!
source:http://edpharmacologystuff.blogspot.com/2008_01_01_archive.html


Video, How Tranquilizer (BZD) affects GABA 
Click HERE for 1min video animation on BZD/GABA works


Video Tutorial on Depressant, Tranquilizers and Antidepressants

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Cocktail of Drugs that killed MJ
Propofol - hypnotic agent or ( general anesthesia) to induce sleep or anesthesia during surgery and may cause partial/complete unconsciousness.





How it works
  • Propofol binds to GABA receptors
  • Causing reduction nerve activity, leads to sedation 
  • Mechanism is similar to BDZ
Drugs that MJ used which led to his death
  • Valium (BDZ)
  • Lorazepam (BZD)
  • Midazopam (BZD)
  • Propofol (Hypnotic)
Dr Sanjay Gupta (CNN) explain how Propofol that killed MJ. Click HERE to view







Video, on Cocktail Drugs that killed MJ
Greatest number of side effects was found in antidepressants.............................MSNBC reports
We miss you MJ and justice shall prevail, rest in peace.......................................Lawrence Kok
Come unto me all who are weary and burdened, and I shall give you rest.........Matthew 11:28
Thanks to all pictures and videos contributors for the above post

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